Testosterone acts through membrane protein GPRC6A to cause cardiac edema in zebrafish embryos Androgen actions are classically thought to be mediated by nuclear androgen receptors, but they can also exert non-genomic effects via binding to integral membrane proteins. Here, Vahid found 3 androgens that cause developmental phenotypes in zebrafish embryos.
Today is a happy day as Hailey successfully defended her thesis and is now Dr Hailey Edwards, PhD. Bittersweet because she will leave the lab at the end of the month to begin a postdoc in San Diego. We will miss her chill enthusiasm and insightful comments at lab meetings.
Hailey’s preprint was submitted to Development in January 2022. The reviewers had good feedback for us, we did some more experiments, and the result is an updated and improved preprint: Hemato-vascular specification requires arnt1 and arnt2 genes in zebrafish embryos. More figures! More movies! More fluorescence imaging! More authors!
Happy New Year! 2022 has to be an improvement over 2021, if only because Hailey’s masterpiece, Hemato-vascular specification requires arnt1 and arnt2 genes in zebrafish embryos, is now available as a bioRxiv preprint. So proud of Hailey for putting this out during a pandemic.
Zebrafish are the tropical minnows advancing genetics and molecular biology. Read the story here.
The 2019 Texas Zebrafish Conference is coming to Houston, November 1-2. Details here We’ll bring together zebrafish researchers from across Texas, Oklahoma, Kansas, Arkansas, Louisiana, and Mexico to discuss research in development, physiology, and genetics, to share new technologies, and network with colleagues in a friendly and supportive environment. The
Check out Paige’s preprint, where she systematically dissects the function of AHR genes (ahr1a, ahr1b, ahr2) in zebrafish craniofacial & fin development and sensitivity to dioxin. And there’s some bonus estrogen receptor experiments in there too! Read the preprint here.
Congrats to Cammie & Shannon! Their paper ‘G protein-coupled estrogen receptor is not required for sex determination or ovary function in zebrafish‘ was accepted for publication in the journal Endocrinology.
G protein-coupled estrogen receptor is not required for sex determination or ovary function in zebrafish An important negative result: We find that G protein-coupled estrogen receptor (GPER) is not required for sex determination or ovary development in zebrafish. While nuclear estrogen receptors are clearly involved in sex determination and gonad
During a break from reviewing grants for an upcoming study section, the lab and I went to hear Dr. Jennifer Doudna give a seminar. We use CRISPR-Cas9 extensively to modify the zebrafish genome, so seeing one of the scientists who discovered CRISPR and adapted it for targeted DNA modification in
Gorelick Lab 